Journal articles

Guiding Generative Protein Language Models with Reinforcement Learning

Filippo Stocco, Maria Artigues-Lleixa, Andrea Hunklinger, Talal Widatalla, Marc Güell, Noelia Ferruz

ArXiv

Discovery and language model-guided designof hyperactive transposases

Dimitrije Ivančić, Alejandro Agudelo, Jonathan Lindstrom-Vautrin, Jessica Jaraba-Wallace, Maria Gallo, Ravi Das, Alejandro Ragel, Irene Higueras, Federico Billeci, Marta Sanvicente, Paolo Petazzi, Noelia Ferruz, Avencia Sánchez-Mejías, Marc Güell

Research Square

Synthetically-programmed antioxidant delivery by a domesticated skin commensal

Guillermo Nevot*, Javier Santos-Moreno*+, Nil Campamà-Sanz, Lorena Toloza, Cristóbal Parra-Cid Patrick A.M. Jansen, Içvara Barbier, Rodrigo Ledesma-Amaro, Ellen van H. den Bogaard and Marc Güell+

Cell Systems 2025

Microbiome characterization of skin biopsies in Spanish patients with hidradenitis suppurativa shows a decrease in D1 and H1 lineages of Cutibacterium acnes

Jorge Romaní, Carles Rosés, François Brillet, Javier Fernández-Vela, Carlos Muñoz-Santos, María José Fábrega, Lorena Toloza, Maria Pol Cros, Marc Güell, Antonio Guilabert

British Journal of Dermatology

Integration of the LacZ and CFTR transgene using Find and cut-and-transfer (FiCAT)

RA Bandara, G Langeveld, ZR Chen, C Duan, ZP Zhou, A Wong, A Sánchez-Mejías, M Güell, J Hu

Journal of Cystic Fibrosis

KMAP: Kmer Manifold Approximation and Projection for visualizing DNA sequences

Chengbo Fu, Einari A. Niskanen, Gong-Hong Wei, Zhirong Yang, Marta Sanvicente-García, Marc Güell, Lu Cheng

BioarXiv

Intein-mediated thyroid hormone biosensors: towards controlled delivery of hormone therapy

Quim Martí-Baena, Andreu Pascuet-Fontanet, Tomas Berjaga-Buisan, Miriam Caravaca-Rodríguez, Jaume Puig-Costa-Juss, Avencia Sanchez-Mejias, Dimitrije Ivančić, Sira Mogas-Díez, Marc Güell, Javier Macia

Frontiers in Systems Biology

Sharper scissors: How TREX2 fine-tunes CRISPR-Cas9 nickases for precise editing

Marc Güell

Molecular Therapy-Nucleic Acids

Delivery of a sebum modulator by an engineered skin microbe in mice

Nastassia Knödlseder, María-José Fábrega, Javier Santos-Moreno , Joan Manils, Lorena Toloza, Maria Marín Vilar, Cristina Fernández , Katrina Broadbent, Julien Maruotti, Hélène Lemenager, Carlo Carolis, Christos C. Zouboulis, Concepció Soler, Rolf Lood, Holger Brüggemann and Marc Güell

Nature Biotechnology 2024