Delivery of a sebum modulator by an engineered skin microbe in mice
Nastassia Knödlseder, María-José Fábrega, Javier Santos-Moreno, Joan Manils, Lorena Toloza, Maria Marín Vilar, Cristina Fernández, Katrina Broadbent, Julien Maruotti, Hélène Lemenager, Carlo Carolis, Christos C. Zouboulis, Concepció Soler, Rolf Lood, Holger Brüggemann & Marc Güell
Nature Biotechnology
New insights into the role of Cutibacterium acnes-derived extracellular vesicles in inflammatory skin disorders
Maria Pol Cros, Júlia Mir-Pedrol, Lorena Toloza, Nastassia Knödlseder, Julien Maruotti, Christos C. Zouboulis, Marc Güell & Maria-José Fábrega
Scientific Reports
CRISPR-Analytics (CRISPR-A): A platform for precise analytics and simulations for gene editing
Marta Sanvicente-García, Albert García-Valiente, Socayna Jouide, Jessica Jaraba-Wallace, Eric Bautista, Marc Escobosa, Avencia Sánchez-Mejías, Marc Güell
Plos Computational Biology 2023
Evolution of CRISPR-associated endonucleases as inferred from resurrected proteins
Borja Alonso-Lerma, Ylenia Jabalera, Sara Samperio, Matias Morin, Almudena Fernandez, Logan T. Hille, Rachel A. Silverstein, Ane Quesada-Ganuza, Antonio Reifs, Sergio Fernández-Peñalver, Yolanda Benitez, Lucia Soletto, Jose A. Gavira, Adrian Diaz, Wim Vranken, Avencia Sanchez-Mejias, Marc Güell, Francisco J. M. Mojica, Benjamin P. Kleinstiver, Miguel A. Moreno-Pelayo, Lluis Montoliu & Raul Perez-Jimenez
Nature Microbiology 2023
INSERT-seq enables high-resolution mapping of genomically integrated DNA using Nanopore sequencing
Dimitrije Ivančić, Júlia Mir-Pedrol, Jessica Jaraba-Wallace, Núria Rafel, Avencia Sanchez-Mejias & Marc Güell
Genome Biology 2022
Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting
Nastassia Knoldlseder, Guillermo Nevot, María-José Fábrega, Júlia Mir-Pedrol, Marta Sanvicente-García, Nil Campanà-Sanz, Bernhard Paetzold, Roolf Lood, Marc Güell
PLOS Pathogens 2022 in press
Find and cut-and-transfer (FiCAT) mammalian genome engineering
Maria Pallarès-Masmitjà+, Dimitrije Ivančić+, Júlia Mir-Pedrol, Jessica Jaraba-Wallace, Tommaso Tagliani, Baldomero Oliva, Amal Rahmeh, Avencia Sánchez-Mejías* & Marc Güell*
Nature Communications 2021
(Horizon 2020, Fundació Ramón Areces)
*Selected among top 25 2021 papers in Life Sciences
DNA Damage Protection for Enhanced Bacterial Survival Under Simulated Low Earth Orbit Environmental Conditions in Escherichia coli
Jaume Puig, Nastassia Knödlseder, Jaume Quera, Manuel Algara, and Marc Güell
Frontiers in Microbiology – Extreme biology section 2021
Establishing a cell-free transcription-translation platform for Cutibacterium acnes to prototype engineered metabolic and synthetic biology
María-José Fábrega, Nastassia Knödlseder, Guillermo Nevot, Marta Sanvicente, Lorena Toloza, Javier Santos-Moreno, and Marc Güell
ACS Biomaterials Science and Engineering 2021
From Dysbiosis to Healthy Skin: Major Contributions of Cutibacterium acnes to Skin Homeostasis.
Miquel Rozas, Astrid Hart de Ruijter, Maria Jose Fabrega, Amine Zorgani, Marc Guell, Bernhard Paetzold and Francois Brillet
Microorganisms 2021
